Synthesis, Radiolabeling, and Biological Evaluation of 5‑Hydroxy-2‑[ 18 F]fluoroalkyl-tryptophan Analogues as Potential PET Radiotracers for Tumor Imaging

癌症PET成像

放射性示踪剂

Aiming at developing mechanism-based amino acid 18F-PET tracers for tumor imaging, we synthesized two 18F-labeled analogues of 5-hydroxy-l-[β-11C]tryptophan ([11C]5HTP) whose excellent in vivo perfo

NIAID Data Ecosystem60

N ‑Methylation of iso DGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent

癌症PET成像

整合素靶向配体

Specific targeting of the integrin subtype α5β1 possesses high potential in cancer diagnosis and therapy. Through sequential N-methylation, we successfully converted the biselective α5β1/αvβ6 peptide

NIAID Data Ecosystem40

Table S1 - HER1-Targeted 86Y-Panitumumab Possesses Superior Targeting Characteristics than 86Y-Cetuximab for PET Imaging of Human Malignant Mesothelioma Tumors Xenografts

癌症PET成像

HER1受体表达分析

Relative in vitro expression of HER1 in human mesothelioma cells determined by FACS based assay. MFI = mean fluorescence intensity. (DOC)

Figshare2015-12-02 更新10