The dysregulation of gene dosage due to duplication or haploinsufficiency is a major cause of autosomal dominant diseases such as Alzheimer's disease. However, there is no rapid and efficient method f

NIAID Data Ecosystem40

Generation of diffuse intrinsic pontine glioma mouse models by brainstem targeted in utero electroporation

脑肿瘤研究

基因编辑技术

Diffuse intrinsic pontine gliomas (DIPGs) are highly lethal childhood brain tumors. Their unique genetic makeup, pathological heterogeneity, and brainstem location all present challenges to treatment.

干细胞与再生医学数据中心2022-02-20 更新110

Pt4 Lhcx1 knockout using TALEN

藻类基因编辑

基因编辑技术

We generated knockout lines of the antenna protein Lhcx1 in Phaeodactylum tricornutum using a TALEN approach. We designed two TALEN pairs and greated three knockout lines (x1KO_1a/1b and x1KO_2)

NIAID Data Ecosystem50

Homo sapiens Raw sequence reads. Homo sapiens

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