Effect of somatostatin knockout on sexually dimorphic hepatic gene expression. Mus musculus

The liver is one of the most sexually dimorphic organs as measured by gene expression differences. About 80% of the sexually dimorphic genes are known to be regulated by growth hormone (GH). Somatostatin (SST) inhibits the release of GH. We generated a SST-knockout mouse and analyzed the hepatic gene expression changes in both sexes. Overall design: We used liver samples from three mice of both sexes and somatostatin genotypes. Mouse background was C57BL/6.