Pathway analysis of genes in JVM-2 cells transfected with control shRNA or p53-specific shRNA consistently altered by KPT185.

The significance of the association between the data set and the canonical pathway was determined based on a ratio of the number of genes from the data set that map to the pathway divided by the total number of genes that map to the canonical pathway and a p-value calculated using Fischer’s exact test determining the probability that the association between the genes in the data set and the canonical pathway is due to chance alone.Pathway analysis of genes in JVM-2 cells transfected with control shRNA or p53-specific shRNA consistently altered by KPT185.