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Organocatalytic Enantioselective Direct Vinylogous Michael Addition of α,β-Unsaturated γ‑Butyrolactam to β‑Acyl Acrylates and 1,2-Diacylethylenes

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NIAID Data Ecosystem2026-03-07 收录
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https://figshare.com/articles/dataset/Organocatalytic_Enantioselective_Direct_Vinylogous_Michael_Addition_of_Unsaturated_Butyrolactam_to_Acyl_Acrylates_and_1_2_Diacylethylenes/2208580
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资源简介:
A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
创建时间:
2016-02-15
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