FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)

FURIN is the most likely endopeptidase that cleaves the BACE propeptide domain (BACE1(22-45)) to form the mature enzyme (7K-BACE1(46-501). Although the pro-enzyme possesses proteolytic activity, this activity is approximately doubled following removal of the prodomain (Bennett et al. 2000).

FURIN 极有可能是切割 BACE 前肽域（BACE1(22-45)）以形成成熟酶（7K-BACE1(46-501)）的终末肽酶。尽管前体酶具备蛋白酶活性，但该活性在去除前肽域（Bennett 等人，2000年）之后大约翻倍。