Effect of the treatment oxaliplatin and/or metformin (100 or 200 mg/kg) on body weight in A) non-diabetic mice (experiment I) and B) diabetic mice (experiment II).

Mice [except saline group] were injected with 1,2-dimethylhydrazine (DMH) weekly for 15 week to induce colon cancer then treated with oxaliplatin and/or metformin (100 or 200 mg/kg) for 4 weeks. Percent change in BWt was calculated using a formula: % change BWt = [(final BWt- baseline BWt)/baseline BWt] x 100. Baseline BWt: was recorded at the end of week 4 and final BWt was recorded at the end of week 24. Results are expressed as mean ± S.E.M and analyzed using two-way ANOVA followed by Tukey's post-hoc test at Pt test.