GNA14, GNA11 and GNAQ mutations are frequent in benign but not malignant cutaneous vascular tumors

In our study, we analyzed a representative cohort of benign vascular proliferations observed in a clinical routine setting as well as a selection of malignant vascular proliferations Our cohort of 104 vascular proliferations including hemangiomas, malformations, angiosarcomas and Kaposis sarcoma were screened by targeted next-generation sequencing for activating genetic mutations known or assumed to be potentially relevant in vascular proliferations