Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials

We established patient-derived organoids and monolayer culture cells from the salivary gland cancer cases. To compare the RNA profiles of primary culture cells (Organoids and monolayer culture cells) and their parental tumors, we isolated total RNA from 2 cases of the salivary gland cancer and performed transcriptome sequencing for the organoids, monolayer culture cells, and their parental tumors of both cases. Case 6 is a case of adenoid cystic carcinoma and Case 11 is a case of salivary duct carcinoma. Overall design: Comparative gene expression profiling analysis of the primary tumor, the organoids, and the monolayer culture cells from cases 6 and 11.