Mice with a human immune system (humanized mice), generated by transplantation of human hematopoietic stem and progenitor cells (HSPCs), serve as invaluable tools to study the development and function
Colonization efficiency and immune stimulation after human microbiota inoculation in mice is known to be poor compared to mouse microbiota inoculation. We tested the colonization efficiency and immune
Humanized bone marrow-liver-thymic (hu-BLT) mice develop a functional immune system in periphery, nevertheless, have a limited reconstitution of human myeloid cells, especially microglia, in CNS. Furt