Percent of trans-eQTL signals1 showing evidence of cis-mediation according to LD between the lead trans-eSNP and the lead cis-eSNP and the P-threshold for trans-eQTL analysis.

1The trans-eQTL signals presented are probe-level signals.2r2 is a measure of LD between the lead SNP for the trans-eQTL signal and the lead cis-eSNP for the potentially mediating transcript (i.e., probe).3P-threshold of 8.4×10−9 corresponds to the significance threshold used in Table 1 (FDR of 0.05). At this threshold, the 189 signals with a cis-probe and the 245 signals without a cis-probe constitute the 434 eQTL signals (comprised of 414 unique genes reported in Table 1).4Mediated is defined as trans-eQTL signals with a “mediation proportion” estimate>0 and Sobel P−5.Percent of trans-eQTL signals1 showing evidence of cis-mediation according to LD between the lead trans-eSNP and the lead cis-eSNP and the P-threshold for trans-eQTL analysis.