Metadata record for the article: Interim Clinical Trial Analysis of Intraoperative Mass Spectrometry for Breast Cancer Surgery

Summary

This
metadata record provides details of the data supporting the claims of the
related article: “Interim Clinical Trial Analysis of
Intraoperative Mass Spectrometry for Breast Cancer Surgery”.

The
related study describes the ex vivo
intraoperative clinical application of mass spectrometry (MS) using a liquid
micro-junction surface sample probe (LMJ-SSP) to assess breast cancer margins.

Type of data:
lipidomics; mass spectrometry using a liquid
micro-junction surface sample probe

Subject of
data: Homo sapiens

Sample size:
breast conserving surgery (BCS) specimens from 21 subjects

Population
characteristics: treatment naive females over 18 years of age, with invasive
breast cancer who were breast conservation therapy candidates at presentation

Recruitment:
Participants were recruited at a clinic visit by their treating surgeon
co-investigator. Eligible patients were introduced to the study by their care team
and, if interested, met with a member of the research team for further
discussion and screening. If agreeable to participate, the patient and surgeon
went through the informed consent form together and sign where applicable.

Trial
registration number: NCT02335671

Data
access

The de-identified
lipidomics data underlying Figures 2-5 in the related article are contained in
the Excel spreadsheet ‘SI_Table_Breast_MassSpec_Aligned_TIC.xlsx’, which is
shared publicly as part of this data record. A copy of the same data is also available
as Supplementary Table 1 of the article.

Corresponding author(s) for this study

Nathalie
Y. R. Agar, Department of Neurosurgery, Brigham and Women's Hospital, Harvard
Medical School, Boston, MA 02115. [e-mail]

Study approval

Approved
by Dana-Farber Cancer Institute IRB. Written informed consent was obtained from
all subjects.