HQ MAGs (CheckM comp≥90%, contam≤5%) from the MicroToxBol Bolivian human gut microbiome cohort

Using gene-level and species-level shotgun metagenomics, we provide the first characterization of the rural, Bolivian microbiome; we identified microbial genes which strongly correlate (rho>0.45) with arsenic in urine, and that overall contribute to substantiate that the gut microbiome helps tolerate arsenic via a evict-out-of-house mechanism. Mediation analysis, followed by phylogenetic investigation of metagenomic-assembled genomes, further strengthens this observation. This study elucidates the role of the microbiome in helping to tolerate arsenic-rich environments, and paves the way for probiotic interventions that may mitigate the effects of this toxic metal. This repository contains 2,478 HQ MAGs from the MicroToxBol cohort in fasta format and a descriptive table comprising taxonomic annotation, quality-checks, and coverage estimation.