Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D‑aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
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It is well documented and accepted that learning and memory processes rely on physiological functioning of the glutamate receptor N-methyl-D-aspartate (NMDAR). Both animal and human studies investigating NMDA itself, experiments with NMDAR antagonists and mutant mice lacking NMDAR subunits strongly support this statement (Rezvani, 2006)....
