Organocatalytic Asymmetric Michael-Hemiacetalization Reaction Between 2‑Hydroxyacetophenones and Enals: A Route to Chiral β,γ-Disubstituted γ‑Butyrolactones
收藏NIAID Data Ecosystem2026-03-10 收录
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资源简介：
The first highly enantioselective organocatalytic reaction employing 2-hydroxyacetophenones is disclosed, namely Michael-hemiacetalization reaction of 2-hydroxyacetophenones with enals. The combination of a primary amine and a secondary amine catalyst was found to be the best choice for this methodology. The products of this reaction were obtained in high enantio- and diastereoselectivities and were converted to a variety of biologically important γ-butyrolactones.
创建时间：
2017-06-01
