Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue. Mus musculus strain:C57BL/6

HFD feeding induces a rapid adipocyte progenitors proliferation in visceral adipose tissue, followed by a block of differentiation. In contrast, subcutaneous adipose tissue, in obesity, undergoes trans-differentiation of beige adipocytes to white and, consequently, a hyperplastic growth at later stages. We profile RNA pol II recruitment and the global epigenetic changes of H3K4me1 and H3K27Ac induced by HFD feeding using ChIP-seq data and investigate the global transcriptomic changes induced by HFD feeding using RNA-seq data.