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Total Synthesis of (±)-Aspergilline A

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NIAID Data Ecosystem2026-03-10 收录
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The total synthesis of (±)-aspergilline A (1) is described. Key features of the synthesis include pyrrolinone formation via reaction of an intermediate propargyl amine with a methyl malonyl chloride derived ammonium enolate and a formal [3+2] cycloaddition between an imidate and cyclopropenone.

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2017-12-15
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