Transcriptome analysis of kidneys of cisplatin-induced AKI model

This study was aimed to investigate the role and underlying mechanism of TRPM2 in cisplatin nephrotoxicity. Cisplatin-induced acute kidney injury (AKI) model was established in WT and TRPM2-KO mice. The transcriptome profiling of  the kidneys of WT and TRPM2-KO mice treated with cisplatin was compared to find differentially expressed gene which may be related to TRPM2 on cisplatin nephrotoxicity. RNA-Seq was applied to detect the differentially expressed gene between the kidneys of WT and TRPM2-KO mice. All mice were treated with 18 mg/kg cisplatin for 72h.