Palladium(II)-Catalyzed, Heteroatom-Directed, Regioselective C–H Nitration of Anilines Using Pyrimidine as a Removable Directing Group

A new
palladium-catalyzed, heteroatom-directed strategy for C–H
nitration of anilines is described. This C–H functionalization
reaction is highly ortho-selective and results in
very good yields. The highlight of the work is the use of pyrimidine
as the removable directing group. This approach constitutes one of
the rare methods of ortho-nitration of anilines,
a reaction that is normally very difficult to achieve via traditional
approaches.