Organocatalytic Enantioselective Michael Addition between 3‑(3-hydroxy‑1<i>H</i>‑pyrazol-1-yl)Oxindole and β<i>-</i>Nitrostyrene for the Preparation of Chiral Disubstituted Oxindoles
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资源简介：
A new enantioselective Michael addition between 3-(3-hydroxy-1H-pyrazol-1-yl)oxindole, a new synthon generated from isatin N,N′-cyclic azomethine imine 1,3-dipole, and β-nitrostyrene has been disclosed. A series of chiral 3-(3-oxo-2,3-dihydro-1H-pyrazol-1-yl) disubstituted oxindoles were obtained in excellent results (up to 97% yield, up to 94% ee) with moderate to good diastereoselectivities (up to 4.3:1 dr).
创建时间：
2020-06-25
