ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis

Figure 1. ZSCAN4 is a centromeric protein related to the proper maturation of mouse oocytes.Figure 2. ZSCAN4 depletion causes centromere stretching due to microtubule pulling forces.Figure 3. ZSCAN4 depletion impairs the recruitment of CENP-A, HEC1, and BubR1 at centromeres and kinetochores.Figure 4. ZSCAN4 depletion disrupts pericentric heterochromatin assembly and chromosome architecture.Figure 5. ZSCAN4 is essential for maintaining centromere integrity during prophase I arrest.Figure 6. ZSCAN4 depletion impairs DNA repair by disrupting chromosomal relocation of the CIP2A-MDC1-TOPBP1 complex.