T2R-TTL-PROTAC3 complex

T2R-TTL-PROTAC3 complex Descriptor: (1S,2R,3S,5S,6S,16E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16-tetraen-6-yl 4-(2-{4-[4-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-4-oxobutyl]-1H-1,2,3-triazol-1-yl}ethyl)benzoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... Authors: Maiocchi, A, Abel, A.-C, Boiarska, Z, Steinmetz, M.O, Passarella, D, Prota, A.E. Deposit date: 2024-10-15 Release date: 2025-10-29 Last modified: 2026-05-13 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras Biorxiv, 2025