Hip1 complex with inhibitor #2 (Hip1-2) via Ser228

Hip1 complex with inhibitor #2 (Hip1-2) via Ser228 Descriptor: GLYCEROL, N-carboxy-L-phenylalanyl-N-{(2S,3R)-3-hydroxy-4-methoxy-4-oxo-1-[(3R)-2-oxo-3,4-dihydro-2H-pyrrol-3-yl]butan-2-yl}-L-lysinamide, Protease Authors: Yim, M.K, Schumann, N.C, Goldfarb, N.E, Johnson, S.J. Deposit date: 2024-12-05 Release date: 2025-12-17 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis. Eur J Med Chem Rep, 15, 2025