Absolute proteome analysis of colorectal mucosa, adenoma and cancer reveals drastic changes in fatty acid metabolism and plasma membrane transporters

Data from ProteomeXchange, PXD ID: PXD002137. Experiment: NOR9_T, file: 20120109_EXQ6_JRW_SA_NOR9_T_05.mzml. Published as part of J Proteome Res. 2015 Aug 6 . From the Abstract: {{i}} Colorectal cancer is a leading cause of cancer-related death. It develops from normal enterocytes, through a benign adenoma stage, into the cancer and finally into the metastatic form. We previously compared the proteomes of normal colorectal enterocytes (N), cancer (C) and nodal metastasis (M) to a depth of 8,100 proteins and found extensive quantitative remodeling between normal and cancer but not cancer and metastasis ... Here we utilize advances in the proteomic workflow to perform an in depth analysis of the normal tissue (N), the adenoma (A) and the cancer (C). {{/i}}