LNA modified G-quadruplex with flipped G-tract and central tetrad

NIAID Data Ecosystem2026-05-02 收录

G-四链体结构

核酸化学修饰

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LNA modified G-quadruplex with flipped G-tract and central tetrad

创建时间：

2024-05-15

Structure of the Human G-quadruplex reveals a novel topology

G-四链体结构

端粒生物学

Structure of the Human G-quadruplex reveals a novel topology Descriptor: 5'-D(*(BRU)P*AP*GP*GP*GP*(BRU)P*TP*AP*GP*GP*GP*T)-3', POTASSIUM ION, SODIUM ION Authors: Parkinson, G.N, Lee, M.P.H, Neidle, S.

Protein Data Bank Japan2024-02-07 更新130

Kinetic parameters for different 2′-OMeN substituted Eco RI sequences.

核酸化学修饰

序列活性分析

Letters and capitals represent 2′-OMeN and DNA nucleotide, respectively. In parentheses are the relative values of modified substrate compared to unmodified control.

NIAID Data Ecosystem40

RNA oligonucleotide containing a 3'-deoxyapio-T

核酸化学修饰

RNA疗法

RNA oligonucleotide containing a 3'-deoxyapio-T

NIAID Data Ecosystem10

Structure and Stability of Human Telomeric G-Quadruplex with Preclinical 9-Amino Acridines

抗癌药物靶点研究

G-四链体结构

G-quadruplexes are higher-order DNA structures formed from guanine-rich sequences, and have been identified as attractive anticancer drug targets. Elucidating the three-dimensional structure of G-quad

NIAID Data Ecosystem60

DNA G-quadruplex structures obtained through MD-based folding procedure

G-四链体结构

分子动力学折叠模拟

The dataset contains structures of DNA G-quadruplexes (G4s), obtained through steered molecular dynamics simulations, for 128 oligonucleotides capable of forming 3- and 2-tetrad G4s. The general seque

Most Wiedzy Open Research Data Catalog20

LNA modified G-quadruplex with flipped G-tract and central tetrad

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