Expression data from T47D/S2 (control) and T47D/TR-2 (tamoxifen-resistant) cell lines
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE221439
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资源简介：
Basal expression profiling was performed to understand molecualr pathways specifically altered in tamoxifen-resistant cells. Tamoxifen is the most accepted targeted agent for treating patients with estrogen receptor (ER)-positive breast cancer (BC), but its efficacy has been limited due to drug resistance, manifested as disease recurrence and eventually death. Metabolic reprogramming of lipids has recently been recognized as a new mode of therapeutic resistance in various cancers. Therefore, we investigated previously unrecognized perturbations in lipid metabolism in tamoxifen-resistant BC by conducting comprehensive metabolomics and transcriptomics analysis. T47D/S2 control cells and T47D/TR-2 tamoxifen-resistant cells were maintained in RPMI 1640 (pheno red-free) medium + 2% FBS + glutamax + insulin. T47D/TR-2 cells were maintained with 1 μM tamoxifen. Both cells were subjected for microarray analysis in duplicates, using Affymetrix gene profiling.
创建时间：
2024-01-01
