An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia
收藏NIAID Data Ecosystem2026-03-10 收录
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资源简介：
The E1099K mutation of NSD2 leads to increased dimethylation of H3K36, activating oncogenic gene expression programs. NSD2-mutant cells acquire several malignant phenotypes and demonstrate increased invasion into mouse brain parenchyma. Identification of aberrantly expressed genes and pathways provides avenues for therapeutic intervention in NSD2-dysregulated malignancy.
创建时间：
2018-03-15
