As the desire for a shortened design/make/test/learn cycle increases in early drug discovery, the pressure to rapidly deliver drug metabolism pharmacokinetic data continues to rise. From a bioanalytic
1. The aim of this study was to evaluate the role of intestinal esterases on the absorption process of tenofovir disoproxil fumarate (TDF). 2. The esterase inhibition capacity of fruit juices (FJs) ri
* POR measured as Cytochrome c reductase activity as in Table 1** Vmax is based on 4-OH-Cy formedCLint Calculated as Vmax/KmCyclophosphamide at different concentrations was incubated in 2 independent