In vivo and in vitro Cu,br/Cu,pl of 62 proprietary compounds.
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In vivo Cu,br/Cu,pl were obtained from total brain plasma ratios (Cbr/Cpl) by using in vitro determined fu,br from brain slice and fu,pl values according to: Cubr/Cupl = Cbr/Cpl×fubr/fupl. In vivo values were considered to approach steady-state when the time when samples were taken after at least 3.5 half-lives.
创建时间：
2015-12-02
