Epigenomic Landscapes Define Differential JAK Inhibitor Sensitivity in IFN-γ-Primed Human Macrophages [ATAC-seq]
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE244128
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We analyzed ATAC sequences to demonstrate selective regulation of genetic programs by JAKi in IFN-γ primed human macrophages. To investigate the suppressive impact of JAK inhibitors (JAKi) on macrophages primed with IFN-γ, THP-1 monocytes were co-treated with PMA for differentiation and IFN-γ for priming, followed by a JAKi (tofacitinib) treatment.
创建时间:
2025-06-24



