REGENERATION-ACTIVATING ROLE OF 6-AMINOPURINE IN A BIODEGRADABLE COLLAGEN–HYDROGEL SYSTEM

This study investigates the regenerative-stimulating role of 6-aminopurine incorporated into a biodegradable collagen–hydrogel system designed for wound healing applications. Collagen, as a natural extracellular matrix component, provides biocompatibility, biodegradability, and structural support for cell attachment and proliferation. The integration of 6-aminopurine into the hydrogel matrix enables controlled local delivery of the bioactive compound, enhancing cellular activity and tissue regeneration processes. Physicochemical characterization of the collagen–hydrogel system included evaluation of swelling behavior, degradation rate, mechanical stability, and drug release kinetics. Biological assessments demonstrated accelerated epithelialization, improved granulation tissue formation, and enhanced collagen organization in treated wounds compared to control groups. The biodegradable nature of the matrix allows gradual resorption without the need for removal, minimizing secondary tissue damage. The findings suggest that 6-aminopurine–loaded collagen hydrogels represent a promising biomaterial platform for regenerative medicine and advanced wound therapy.