Kitasatospora aureofaciens Genome sequencing and assembly. Kitasatospora aureofaciens

Streptomyces aureofaciens is a Gram-positive actinomycete that capable of producing four tetracycline antibiotics, Chlortetracycline (CTC), tetracycline (TC), 6-demethylchlortetracycline (6-DCT) and 6-demethyltetracycline (6-DMT). Firstly reported by McCormick in 1957, 6-DCT has become an important industrial material used for production of semisynthetic tetracyclines. Thus far, the high-yielding industrial producer of 6-DCT is obtained from continuous “random mutagenesis and screening” procedures, which limit the yield improvement of current producer using same strategy. The availability of the genome sequence of Streptomyces aureofaciens DM-1 will provide foundation for functional genomics, biosynthetic pathways and heterologous expression of 6-DCT.