Adult Lung Health Study

The Adult Lung Health Study was a propective cohort study conducted in Chikhwawa, rural Malawi, between August 2014 and November 2017. The published manuscript can be found at http://dx.doi.org/10.1136/thoraxjnl-2019-213941
Data were collected at baseline and 2 follow-up visits from a population-representative sample of adults (aged 18 or over). At each time-point participants completed a respiratory symptom questionnaire, performed pre- and post-bronchodilator spirometry and underwent a 48-hour period of personal air pollution monitoring.
1481 adults were recruited between August 2014 and July 2015.
Spirometry data (meeting BOLD [Burden of Obstructive Lung Disease] Study QC standards) were collected for 886 participants at baseline, 594 participants at first follow-up and 537 participants at second follow-up. Spirometry was performed before and after administration of 200 microgram salbutamol, via Volumatic spacer. Spirometry measurements were considered repeatable if there were 2 acceptable traces within 200ml of each other.
Personal air pollution exposure data were collected using Aprovecho monitors (measuring carbon monoxide and fine particulate matter), worn by each participant for a period of 48-hours. In order to minimise missing data and ensure measurements represented a full 24-hour cycle, readings were truncated at 24-hours. Aprovecho data were available for 1029 participants at baseline, 830 at first follow-up and 811 at second follow-up.

《成人肺部健康研究》是一项在马拉维奇克瓦瓦农村地区进行的纵向队列研究，该研究始于2014年8月，持续至2017年11月。该研究的已发表手稿可在以下链接查阅：http://dx.doi.org/10.1136/thoraxjnl-2019-213941。研究数据于基线以及两次随访访问中收集，研究对象为18岁及以上的成年人群。在每一个时间点，参与者均需完成呼吸症状问卷，进行支气管扩张剂前后肺功能检测，并经历为期48小时的个人空气污染监测。在2014年8月至2015年7月期间，共招募了1481名成年人。符合BOLD（阻塞性肺疾病负担）研究质量控制的肺功能数据在基线时收集于886名参与者，首次随访时收集于594名参与者，第二次随访时收集于537名参与者。通过Volumatic间隔器给予200微克沙丁胺醇后，肺功能检测被认为可重复，如果两次可接受的轨迹之间的体积相差不超过200毫升。使用Aprovecho监测器（测量一氧化碳和细颗粒物）收集个人空气污染暴露数据，每个参与者佩戴48小时。为了最大限度地减少数据缺失并确保测量数据代表了一个完整的24小时周期，读数被截断至24小时。基线时，Aprovecho数据可供1029名参与者使用，首次随访时为830名，第二次随访时为811名。