TAtouScan reference database

This archive contains the reference database used by TAtouScan to annotate and score toxin-antitoxin (TA) systems. TAtouScan is a command-line tool designed to identify TA systems in genomes and metagenomes. It uses HMM profiles to detect toxin and antitoxin genes, and compares predicted pairs against reference statistics to assign a match score. The archive extracts to a single directory (tatouscan_db/) containing four files: ta.hmm : HMM profiles (HMMER3 format) representing known toxin and antitoxin protein families, sourced from TASmania, TADB3, and additional literature. hmm_info.tsv: Metadata for each HMM profile: family name, type (Toxin or Antitoxin), source database, and description. family_statistics.tsv: Per-family reference statistics (median, MAD, and counts) for three structural features: toxin size, antitoxin size, and intergenic distance, derived from known TADB3 type-II TA systems. Used to compute Z-scores for scoring. known_pairs.tsv: Known toxin-antitoxin family co-occurrences from TADB3. Used to assess whether a predicted pair matches a previously observed family combination.