Summary of inbreeding coefficient estimates across cohorts, and association testing.

For each case and control group we present the average the estimated inbreeding coefficient and the number of individuals with inbreeding coefficients above a specified threshold. The last column indicates the total number of individuals in each group. The bottom two rows indicate the results of an association test between inbreeding and case/control status using either a categorical variable as a definition of inbreeding status (F>0.5%, F>1.6%, and F>6.25%) or using the inbreeding coefficient as a continuous variable (“All F”).