TSTScope reveals T cell phenotypes predictive of immune checkpoint blockade response.
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TSTScope is a multimodal deep learning framework that jointly integrates scRNA-seq and scTCR-seq data. TSTScope utilizes a gene program (GP)-constrained variational autoencoder (VAE) to construct an interpretable latent space, effectively unifying antigen specificity with transcriptional states.
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Zenodo创建时间：
2025-12-26
