Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) table for Small Intestine, v1.3

Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) tables (https://humanatlas.io/asctb-tables) aim to capture<br>anatomical human body parts, the typology of cells, and biomarkers used to identify cell types. The tables are<br>authored and reviewed by an international team of experts. The Small Intestine ASCT+B table represents terms related<br>to the adult human small intestine. These include both macroscopic and microscopic anatomical structures, major cell<br>types, and protein biomarkers specific for each cell type listed. This table was generated based on published<br>histopathologic nomenclature, as well as published literature on cell-type specific biomarkers. Most of the markers<br>listed are observed in more than one study or orthogonally validated. Note that these are predicted markers and a<br>single marker to annotate a cell type is not likely sufficient or specific. Where more refined cell types are not<br>available in the ontologies, the closest general term is used. For example, there are likely multiple types of small<br>intestine stromal cells; however, further characterization is needed to distinguish between these cell types. Where<br>cells of similar type occur in different locations, the closest and highest level of resolution available is used. For<br>example, enterocytes occur in multiple different contexts within the small intestine, including the duodenum, jejunum,<br>and ileum.<br> <br>**Bibliography:** <br><br>* Börner, Katy, Sarah A. Teichmann, Ellen M. Quardokus, James C. Gee, Kristen Browne, David Osumi-Sutherland, Bruce W. Herr II, et al. 2021. “Anatomical Structures, Cell Types and Biomarkers of the Human Reference Atlas.” *Nature Cell Biology* 23 (11): 1117–28. https://doi.org/10.1038/s41556-021-00788-6.