Stereocontrolled Construction of Tetrahydropyrano[2,3‑c]pyrazole Scaffold via an Organocatalyzed Formal [3 + 3] Annulation
收藏数据链接：
官方服务：
资源简介：
A bifunctional squaramide catalyzed enantioselective formal [3 + 3] annulation reaction with pyrazolin-5-ones and nitroallylic acetates has been developed. Densely substituted tetrahydropyrano[2,3-c]pyrazoles with two adjacent stereogenic centers are obtained in a highly stereocontrolled manner. Representative transformation of the annulation product to a biologically important fused dihydroisoquinoline is achieved without any appreciable loss in the diastereo- and enantioselectivity.
创建时间：
2016-05-16
