Comparison of viral neutralisation activity of R1a-B6 and R1a-A5 in a monovalent and bivalent antibody format.

1Neutralisation of laboratory adapted X-181 strain corresponding to A/California/07/2009 (H1N1)pdm09, NIBRG-14, a reverse genetics reassortant of A/Vietnam/1194/2004 (H5N1), NIBRG-147, a reverse genetics reassortant of A/Singapore/01/57 (H2N2), NIBRG-91 a reverse genetics reassortant of A/chicken/Hong Kong/G9/97 (H9N2), NIBRG-109 reverse genetics reassortant of A/New York/107/2003 (H7N2) and seasonal A(H3N2) virus A/Montana/05/2011. 2IC50 is given in nM and is the concentration required to give 50% maximum neutralisation. Results are the mean of 3 or more independent assays. 3– indicates no neutralisation was seen at antibody concentrations less than 1 µM. NT is not tested.