Sexually discordant selection is associated with trait specific morphological changes and a complex genomic response

Sexes often have differing fitness optima, potentially generating intra-locus sexual conflict, as each sex bears a genetic ‘load’ of alleles beneficial to the other sex. One strategy to evaluate conflict in the genome is to artificially select populations discordantly, against established sexual dimorphism, reintroducing attenuated conflict. We investigate a long-term artificial selection experiment reversing sexual size dimorphism in Drosophila melanogaster during ~350 generations of sexually discordant selection. We explore morphological and genomic changes to identify loci under selection between the sexes in discordantly and concordantly size selected treatments. Despite substantial changes to overall size, concordant selection maintained ancestral sexual dimorphism. However, discordant selection altered size dimorphism in a trait-specific manner. We observe multiple, possible soft selective sweeps in the genome, with size related genes showing signs of selection. Patterns of genomi..., See the associated paper in Evolution., , # Data from: Sexually discordant selection is associated with trait specific morphological changes and a complex genomic response

This repository includes all scripts and phenotypic data to reproduce the analyses associated with the manuscript:
Audet T, Krol J, Pelletier K, Stewart AD, Dworkin I. Sexually discordant selection is associated with trait specific morphological changes and a complex genomic response. Evolution. 2024 May 9:qpae071. [doi: 10.1093/evolut/qpae071](https://doi.org/10.1093/evolut/qpae071). PMID: 38720526.

A static copy of this repository (frozen at time of acceptance of the paper) is available on [DRYAD](https://datadryad.org/stash/dataset/doi:10.5061/dryad.6t1g1jx6k).

A [previous pre-print of the manuscript is available here](https://www.biorxiv.org/content/10.1101/2023.08.31.555745v2).

In addition to the phenotypic data, raw sequence data is available through [NCBI SRA, BioProject PRJNA1107500](https://www.ncbi.nlm.nih.gov/sra/PRJNA1107500). This includes th...