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New Synthesis of Optically Active 5-Isoxazolidinones and β-Amino Acids

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NIAID Data Ecosystem2026-03-06 收录
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A new simple and stereoselective synthesis of 5-isoxazolidinones based on the reaction of lithiated 2-isopropyl-2-oxazolines with nitrones is described. A chiral version of such a methodology allows the preparation of highly enantioenriched 5-isoxazolidinones which are useful precursors for the synthesis of β-amino acids

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2003-12-12
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