mRNA expression changes in CCM3-deficient endothelial cells
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下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP221598
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资源简介：
Loss-of-function variants in CCM3/PDCD10 predispose to cerebral cavernous malformations (CCMs) that are vascular lesion of the central nervous system. Using CRISPR/Cas9 genome editing and RNA sequencing, we have shown that long-term inactivation of CCM3 in human endothelial cells dysregulates fibronectin expression and thus impairs the assembly of a functional fibronectin matrix by endothelial cells. Overall design: Examination of the mRNA expression profile of 3 wild-type CI-huVEC lines and 3 clonal CCM3-knockout CI-huVEC lines.
创建时间：
2020-07-09
