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functional anlysis of Chd5 in mouse embryonic stem cells

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NIAID Data Ecosystem2026-03-11 收录
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Chd5 is an essential factor for neuronal differentiation and spermatogenesis, and known as a tumor suppressor. However, it remains unclear how Chd5 remodels chromatin structure. We completely disrupted the Chd5 locus using the CRISPR-Cas9 system to generate a 52 kbp long deletion, and analyzed Chd5 function in mouse embryonic stem cells.

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2020-04-09
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