Comparison of loop modeling results by the average RMSD of main chain atoms (N, Cα, C, and O) of loops in angstroms (Å) on test sets of varying environmental accuracies measured by E-RMSD.

Standard deviations are also reported.1)Loop sampling methods sample only the loop region, while extended sampling methods sample surrounding side chains in addition to the loop.2)Taken from Sellers et al.[15].3)Taken from Mandell et al.[16].4)Results of the best-score models out of 500 models sampled for each target following the protocol provided by Stein et al.[18] with Rosetta v3.5.The results for the crystal structure set and the side chain-perturbed set are the same for NGK because extended sampling of loop environment was used for both sets.5)Loop sets taken from Jacobson et al.[10]. See Tables S1 and S2 for the list of loops.6)Loop sets from Zhu et al.[34]. See Tables S1 and S2 for the list of loops.7)Loop set from Fiser et al.[1]. See Tables S3 for the list of loops.Comparison of loop modeling results by the average RMSD of main chain atoms (N, Cα, C, and O) of loops in angstroms (Å) on test sets of varying environmental accuracies measured by E-RMSD.