Enantioselective Synthesis of Fluoroalkyl-Substituted syn-Diamines by the Asymmetric gem-Difunctionalization of 2,2,2-Trifluorodiazoethane
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We describe a facile strategy for building enantioenriched fluoroalkyl-substituted syn-diamines by the asymmetric gem-difunctionalization of 2,2,2-trifluorodiazoethane, which could be efficiently converted to a series of fluoroalkyl-substituted structures. The proposed key intermediate is an ammonium ylide generated from 2,2,2-trifluorodiazoethane, and its reactivity was further explored by DFT calculations.
创建时间：
2020-03-25
