SNPs associated with resistant hypertension at p−6 in the eMERGE Network in the genome-wide association study.

After removal of ESR1 rs9479122, single-SNP tests of association were performed for 2,530,149 SNPs in eMERGE I and II using logistic regression, assuming an additive genetic model, adjusted for sex, decade of birth, median body mass index, genotyping platform, and genetic ancestry (principal components 1 through 10). Results are shown for tests of association in the eMERGE I and II Network at p−6. Tests of association were repeated for European Americans only using logistic regression, assuming an additive genetic model, adjusted for sex, decade of birth, median body mass index, genotyping platform, and genetic ancestry (principal components 1 through 3). Results are also shown for European Americans for SNPs associated with resistant hypertension at p−6 in the eMERGE I and II Network. Abbreviations: basepair (bp), chromosome (chr), coded allele (CA), coded allele frequency (CAF).