A functional complex between XRN2 and Sam68 orchestrates an alternative polyadenylation program involved in prostate cancer cell cycle progression
收藏NIAID Data Ecosystem2026-03-12 收录
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资源简介：
Alternative cleavage and polyadenylation (APA) of pre-mRNAs yields multiple transcripts differing for their 3'end and its regulation is often dysregulated in human cancers, including prostate cancer (PC). Herein, we uncovered a novel mechanism of APA regulation that impinges on the functional interaction between the 5'-3' exonuclease XRN2 and the RNA binding protein Sam68.
创建时间：
2021-08-06
