Theoretical Insights into the Oxidative Stress-Relieving Properties of PinocembrinAn Isolated Flavonoid from Honey and Propolis

Bee products are a valuable group of substances that
have a wide
range of applications for humans. They contain a high level of polyphenolic
compounds, which have been shown to combat radicals and effectively
reduce oxidative stress. In this study, density functional theory
was utilized to determine the anti-OOH activity, sequestration of
free Cu­(II) and Fe­(III) ions, the potential pro-oxidative activity
of the formed complexes, and the repairing capabilities toward essential
biomolecules. The kinetic constants for scavenging of hydroperoxide
radical were found to be low, with an order of magnitude not exceeding
10–3 M–1 s–1. Chelating properties showed slightly more satisfactory outcomes,
although most complexes exhibited pro-oxidant activity. Pinocembrin,
however, proved effective in repairing oxidatively damaged biological
compounds and restoring their original functionality. The study found
that whilst the system displays limited type I and type II antioxidant
activity, it may support the role of physiological reductants already
present in the biological matrix.