Causal Association Between PDCD5 Expression and the Risk of Biliary System Cancers: A Two-Sample Mendelian Randomization Study Based on Peripheral Blood and Immune Single-Cell eQTLs With Multi-Cohort Validation

Supplementary Information Supplementary File 1: Summary of the paraptosis candidate gene set and exposure-side eQTL/single-cell eQTL information Supplementary File 2: Complete results and robustness analyses from the initial MR screen in the eQTLGen blood cis-eQTL stage Supplementary File 3: Construction of instrumental variables and LD clumping details for GTEx v10 whole-blood eQTLs Supplementary File 4: Complete MR outputs and sensitivity analyses from the GTEx v10 whole-blood eQTL replication stage Supplementary File 5: Multi-cohort GEO differential expression analyses (genome-wide DEG results and PDCD5 validation information) Supplementary File 6: Construction, LD processing, and harmonization of PDCD5 immune single-cell sc(e)QTL instruments (for single-cell MR analyses) Supplementary File 7: Cell type-specific OneK1K immune single-cell sc(e)QTL-MR results and sensitivity analyses