Expression of EYA1 in metanephric mesenchyme

The Eyes absent homolog1 (EYA1) is expressed in metanephric mesenchyme and specifies metanephric mesenchyme, which interacts with the nephric duct to regulate formation of the ureteric bud (inferred from mouse homologs). Odd skipped related 1 (OSR1, also called ODD1) activates expression of EYA1 in the metanephric mesenchyme (inferred from mouse homologs). Mice lacking Eya1 fail to form kidneys (Xu et al. 1999). Mice that lack Osr1 do not express detectable Eya1, indicating an absolute requirement for Osr1 (James et al. 2006). The Osr1 mutants also have abnormalities of the nephric duct and mesonephros and they fail to form metanephric mesenchyme (James et al. 2006).

眼无同源基因1（EYA1）在生肾间充质中表达，并指定生肾间充质，该间充质与输尿管管进行相互作用，以调节输尿管芽的形成（根据小鼠同源基因推断）。奇跳相关1（OSR1，亦称ODD1）激活了生肾间充质中EYA1的表达（根据小鼠同源基因推断）。缺乏Eya1的鼠无法形成肾脏（Xu等人，1999年）。缺乏Osr1的鼠不能检测到EYA1的表达，表明Osr1的绝对必要性（James等人，2006年）。Osr1突变体还表现出输尿管和生肾的异常，并且它们无法形成生肾间充质（James等人，2006年）。